Proceedings of the Komi Science Centre of the Ural Division of the Russian Academy of Sciences Proceedings of the Komi Science Centre of the Ural Division of the Russian Academy of Sciences Известия Коми научного центра УрО РАН 1994-5655 106036 10.19110/1994-5655-2025-7-5-13 Научные статьи Science articles Научные статьи Analysis of the geroprotective potential of retinoic acid in the Drosophila melanogaster model Анализ геропротекторного потенциала ретиноевой кислоты на модели Drosophila melanogaster Тимушева Н. С. Timusheva N. S. uliasheva.n.s@ib.komisc.ru Пакшина Н. Р. Pakshina N. R. pakshina.n.r@ib.komisc.ru Прошкина Е. Н. Proshkina E. N. proshkina.e.n@ib.komisc.ru Москалев А. А. Moskalev A. A. amoskalev@ib.komisc.ru Институт биологии ФИЦ Коми НЦ УрО РАН Сыктывкар Россия Institute of Biology, Komi Science Centre of the Ural Branch of the Russian Academy of Sciences Syktyvkar Russian Federation Институт биологии ФИЦ Коми НЦ УрО РАН Сыктывкар Россия Institute of Biology, Federal Research Center Komi Science Center of the Ural Branch of the Russian Academy of Sciences Syktyvkar Russian Federation Институт биологии ФИЦ Коми НЦ УрО РАН Сыктывкар Россия Institute of Biology, Federal Research Center Komi Science Center of the Ural Branch of the Russian Academy of Sciences Syktyvkar Russian Federation Институт долголетия с клиникой восстановительной и профилактической медицины Российского научного центра хирургии имени академика Б. В. Петровского Москва Россия nstitute of Longevity with a Clinic of Rehabilitation and Preventive Medicine, Russian Science Centre of Surgery named after Academician B. V. Petrovsky Moscow Russian Federation 11 11 2025 11 11 2025 7 5 13 26 08 2024 01 10 2024 https://ras.editorum.ru/en/nauka/article/106036/view

Ретиноевая кислота, производное витамина А, является важным компонентом сигнализации между клетками в организме. В то же время имеются противоречивые данные о ее влиянии на продолжительность жизни организма. В данной работе исследовано влияние ретиноевой кислоты на длительность жизни особей Drosophila melanogaster и их устойчивость к индуктору окислительного стресса параквату. Ретиноевая кислота в концентрациях 10 и 500 мкмоль/л оказала геропротекторный эффект на самок дрозофил, вызвав увеличение медианной продолжительности жизни и возраста 90 % смертности на 2–5 и 6 % соответственно. Но данное вещество не влияло на выживаемость самцов, так же как устойчивость к прооксиданту параквату особей обоих полов. Положительное действие ретиноевой кислоты на продолжительность жизни может быть обусловлено активацией генов репарации ДНК mei-9 и okr.

Retinoic acid, a derivative of vitamin A, is an important component of signaling between cells in an organism. At the same time, there are conflicting data on its effect on the lifespan of organisms. In this work, we have studied the effect of retinoic acid on the lifespan of Drosophila melanogaster and its resistance to the oxidative stress inducer named paraquat. Retinoic acid at the concentrations of 10 and 500 μmol/l exerts a geroprotective effect on female Drosophila, increasing the median lifespan and the 90 % mortality age by 2–5 and 6 %, respectively. However, this substance has not affected the survival rate of males, as well as the resistance to the prooxidant paraquat of flies of both sexes. The positive effect of retinoic acid on the lifespan may be due to the activation of the DNA repair genes mei-9 and okr.

 продолжительность жизни стрессоустойчивость ретиноевая кислота Drosophila melanogaster lifespan stress resistance retinoic acid Drosophila melanogaster Исследования выполнены в рамках государственного задания по теме «Генетические механизмы стрессоустойчивости и контроля продолжительности жизни для поиска новых мишеней для геропротекторных вмешательств на модели Drosophila melanogaster» (№ 125013101228-2). The study was carried out within the framework of the state task on the topic "Geneticheskie mekhanizmy stressoustoichivosti i kontrolya prodolzhitelnosti zhizni dlya poiska novykh mishenei dlya geroprotektornykh vmeshatelstv na modeli Drosophila melanogaster [Genetic mechanisms of stress tolerance and life expectancy control for the search of new targets for geroprotective interventions on the Drosophila melanogaster model]" (№ 125013101228-2).

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